Archives
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br Introduction The cervix is
2021-01-19
Introduction The methosulfate is a poorly studied component of the mare’s reproductive tract. It has anatomical and biological defense mechanisms involved in the delicate balance between immunological tolerance, sperm transport and biological defense. Anatomically, the cervix is composed of epit
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Recent reports revealed that CSE affects
2021-01-19
Recent reports revealed that CSE affects the endothelial cells of various tissues like kidney, liver, heart including Rebastinib [26,30]. The damage of brain endothelial cells enhances the progress of cognitive dysfunction due to the accumulation of toxic free bio-radicals and activation of inflamm
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HCV has evolved mechanisms to evade
2021-01-19
HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 Bromfenac Sodium receptor of the N-terminus of E2, which is referred to as the
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DNA replication checkpoint kinases in both yeast
2021-01-19
DNA replication checkpoint kinases in both yeast and human NSC228155 synthesis upregulate dNTP levels under replication stress to mediate their essential function at replication forks (Yeeles et al., 2013). It is possible that upregulation of dNTP levels under replication stress helps fork restart
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br Introduction Coping with DNA damage
2021-01-19
Introduction Coping with DNA damage is possible thanks to surveillance mechanisms (checkpoints), that detect the problem and promote its solution [1], [2], and to repair and tolerance pathways that remove the lesions or reduce the damage consequences [3], [4]. Failures in these processes have a h
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br Materials and Methods br Acknowledgements br Introduction
2021-01-19
Materials and Methods Acknowledgements Introduction The extracellular matrix (ECM) is a dynamic structure that acts as a scaffold for the mechanical support of multicellular organisms. It is responsible for the organisation of different tissues and regulates critical events in development a
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Fatty acid oxidation plays a
2021-01-18
Fatty 4-P-PDOT β-oxidation plays a crucial role in maintaining body energy homoeostasis mainly during catabolic states. It mainly occurs in mitochondria and involves a cyclical series of reactions that result in the shortening of fatty acids. Fatty acids comprise an efficient source of energy that
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br Acknowledgements This study is
2021-01-18
Acknowledgements This study is sponsored by the Natural Science Foundation of China (grant no. 51178161), 111 Project (grant no. B13024) and the Fundamental Research Funds for the Central Universities (grant no. 2017B00914) Introduction Highway and pavement engineers are facing concrete pavem
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In different body organs a number of biological functions ar
2021-01-18
In different body organs, a number of biological functions are generally mediated by binding of the extracellular substances to the particular transmembrane receptors, which results in subsequent signal stimulation by intracellular signaling cascades. These cascades function over the complex network
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At one time the biological effects of cAMP were
2021-01-18
At one time, the biological effects of cAMP were thought to be mediated exclusively by Protein Kinase A (PKA). Consistent with this, PKA inhibitors have been shown to reverse the effects of cAMP-elevating agents on VSMC proliferation [5]. However, we recently reported that cAMP-mediated inhibition o
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br Transparency document br Introduction The cyclic nucleoti
2021-01-18
Transparency document Introduction The cyclic nucleotide adenosine 3′,5′-cyclic monophosphate (cAMP) exerts both an endothelium-dependent and an endothelium independent vasorelaxant action in rat SB 258719 hydrochloride [1]. cAMP direct, endothelium-independent vasorelaxant effects have been a
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Initial investigations in the heart uncovered Epac
2021-01-18
Initial investigations in the heart uncovered Epac as a positive regulator of myocyte hypertrophy [8], [9]. Concomitantly, Epac has been shown to regulate cardiac Ca homeostasis [8], [10], [11], [12], [13]. Ca is an essential second messenger in the cardiac physiology because its rhythmic variations
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br Acknowledgements The research leading
2021-01-18
Acknowledgements The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 − Scientia Fellows (JB) and the Research Council of Norway (NFR-grant 221444) (JB, JPM, OB). Introduction Hu
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Despite the important agronomic traits
2021-01-18
Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb
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NSC23766 DA neurons are capable of somatodendritic and axona
2021-01-18
DA neurons are capable of somatodendritic and axonal DA release, which may occur at synapses, as well as non-synaptic or asynaptic sites (Trudeau et al., 2014). DA may also be released at different timescales and in response to different DA neuron firing patterns (Grace et al., 2007). Furthermore, s